WDG JR Myelofibrosis Fund

What is Myelofibrosis?

Myelofibrosis is a serious bone marrow disorder that disrupts your body's normal production of blood cells. Why these changes occur is unknown, but the result is extensive scarring in your bone marrow. This in turn leads to severe anemia — causing weakness and fatigue — and enlargement of your spleen and liver, hallmark characteristics of the disease. You may also hear myelofibrosis referred to as agnogenic myeloid metaplasia or idiopathic myelofibrosis.

An uncommon disease, myelofibrosis can occur at any age, although it most frequently develops after age 50. There's no known way to prevent myelofibrosis, and risk factors for it are unclear.

In most cases, myelofibrosis gets progressively worse. Treatment generally focuses on relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.


  • Feeling tired, weak or short of breath, usually because of anemia
  • Pain or fullness below your ribs on the left side, due to enlarged spleen
  • Enlarged liver
  • Pale skin
  • Easy bruising
  • Easy bleeding
  • Excessive sweating during sleep (night sweats)
  • Fever
  • Frequent infections
  • Bone pain
  • Treatment


    • Blood Tranfusions
    • Androgen Therapy
    • Chemotherapy
    • Radiation Therapy
    • Thalidomide with steroids
    • Splenectomy
    • Bone Marrow Transplant
    • Stem Cell Transplant- Allogeneic stem cell transplantation — stem cell transplantation from a suitable donor — is the only treatment that has the potential to cure myelofibrosis.
    •  NEW! Ruxolitinib is a new drug that targets the JAX2 gene that is thought to be the cause of Myelobibrosis.

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