Myelofibrosis is a serious bone marrow disorder that disrupts your body's normal production of blood cells. Why these changes occur is unknown, but the result is extensive scarring in your bone marrow. This in turn leads to severe anemia — causing weakness and fatigue — and enlargement of your spleen and liver, hallmark characteristics of the disease. You may also hear myelofibrosis referred to as agnogenic myeloid metaplasia or idiopathic myelofibrosis.
An uncommon disease, myelofibrosis can occur at any age, although it most frequently develops after age 50. There's no known way to prevent myelofibrosis, and risk factors for it are unclear.
In most cases, myelofibrosis gets progressively worse. Treatment generally focuses on relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.